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| | Siremadlin Basic information |
| Product Name: | Siremadlin | | Synonyms: | (6S)-5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-Pyrrolo[3,4-d]imidazol-4(1H)-one;Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6S)-;Siremadlin (NVP-HDM201);NVP-HDM201;CS-2613;CS-2787;HDM201; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201;(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one | | CAS: | 1448867-41-1 | | MF: | C26H24Cl2N6O4 | | MW: | 555.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1448867-41-1.mol |  |
| | Siremadlin Chemical Properties |
| Boiling point | 736.5±70.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 56.75 mg/mL (102.18 mM) | | pka | 1.33±0.29(Predicted) |
| | Siremadlin Usage And Synthesis |
| Uses | Siremadlin is an oral biologic agent that is a selective inhibitor of the p53-MDM2 interaction and is being investigated for the treatment of patients with myeloid malignancies after showing single agent activity in preclinical studies. the safety profile of Siremadlin did not differ significantly between tumor types and treatment regimens. |
| | Siremadlin Preparation Products And Raw materials |
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