146422-58-4
| 中文名称 | 146422-58-4 |
|---|---|
| 中文同义词 | 化合物 T10731 |
| 英文名称 | CDD0102 |
| 英文同义词 | CDD0102;CDD0102A;Pyrimidine, 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydro-;CDD0102,CDD-0102 |
| CAS号 | 146422-58-4 |
| 分子式 | C8H12N4O |
| 分子量 | 180.21 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 146422-58-4.mol |
| 结构式 |  |
146422-58-4 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
CDD0102 是一种有效的 M1 毒蕈碱 (Muscarinic) 受体激动剂。
mAChR
CDD0102 (CDD-0102) is an efficacious muscarinic agonist in cell lines expressing M 1 receptors. CDD0102 displays much lower activity at M 3 and M 5 receptors.
After i.p. injections, CDD0102 (CDD-0102) crosses the blood-brain barrier (BBB) in a dose-dependent manner. In toxicological studies, the LD 50 of CDD0102 is 190 mg/kg following i.p. injections and greater than 1,000 mg/kg following oral administration. In follow-up studies, after oral administration at a dose of 10 mg/kg, CDD0102 fully reverses memory deficits associated with IgG-192 saporin administration. Again, no side effects are observed at this dose.