222318-55-0
| 中文名称 | 222318-55-0 |
|---|---|
| 中文同义词 | 化合物 T12596 |
| 英文名称 | Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)- |
| 英文同义词 | Pyrrolo[2,3-c]azepine-4,8(1H,5H)-dione, 1-[4-[4-(4-fluorobenzoyl)-1-piperidinyl]butyl]-6,7-dihydro-7-methyl-, 4-oxime, (4E)-;(4E)-SUN9221;(4E)-SUN-9221,(4E)SUN9221,(4E) SUN9221 |
| CAS号 | 222318-55-0 |
| 分子式 | C25H31FN4O3 |
| 分子量 | 454.5370432 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 222318-55-0.mol |
| 结构式 |  |
222318-55-0 性质
| 沸点 | 661.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.29±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 11.20±0.20(Predicted) |
(4E)-SUN9221 是一种有效的 α1-adrenergic receptor 和 5-HT2 receptor 拮抗剂，具有抗高血压和抗血小板聚集的功效。
|
5-HT 2 Receptor
|
α1
|
(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC 50 s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22).
(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR.