栀子苷
| 中文名称 | 栀子苷 |
|---|---|
| 中文同义词 | 栀子苷(京尼平苷,去羟基栀子甙,枝子苷);桷子素葡萄糖苷;枝子苷;京尼平苷,去羟基栀子甙,枝子苷;京尼平甙(标准品);GENIPOSIDE 栀子苷;栀子苷/京尼平甙/栀子甙/去羟基栀子甙/枝子苷/京尼平苷/桷子素葡萄糖苷;栀子苷 20MG;栀子苷 |
| 英文名称 | Geniposide |
| 英文同义词 | GENIPOSIDE;Methyl (1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate;glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-,methyl ester, (1S,4aS,7aS)-;(1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-hydroxymethylcyclopenta[c]pyran-4-carboxylic acid methyl ester;1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid methyl ester;Geniposide ,98%;Olea europaea L;Methyl (1S)-1alpha-(beta-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4aalpha,5,7aalpha-tetrahydrocyclopenta[c]pyran-4-carboxylate (1S)-1alpha-(beta-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4aalpha,5,7aalpha-tetrahydrocyclopenta[c]pyran-4-carboxylic Acid Meth |
| CAS号 | 24512-63-8 |
| 分子式 | C17H24O10 |
| 分子量 | 388.37 |
| EINECS号 | |
| 植物来源 | 栀子 |
| 相关类别 | 植物提取物;中药对照品;标准品;对照品,标准品;分析标准品;中草药成分;对照品;原料药;合成试剂;糖;原料;小分子抑制剂;小分子抑制剂，天然产物;中药标准品;其他原料;Iridoids;Standard extract;Natural Plant Extract;Glucagon receptor and related;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;植物成分单体;标准品-对照品;标准品-中药标准品;标准品 -中药标准品;环烯醚萜;动植物提取;天然高含量单体;主营推荐产品;通用生化试剂-天然产物;日用化学品 |
| Mol文件 | 24512-63-8.mol |
| 结构式 |  |
栀子苷 性质
| 熔点 | 160.0 to 164.0 °C |
|---|---|
| 沸点 | 641.4±55.0 °C(Predicted) |
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | H2O：≥5mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 12.80±0.70(Predicted) |
| 颜色 | 白色至米色 |
| 稳定性 | 吸湿性 |
| LogP | -1.920 (est) |
| CAS 数据库 | 24512-63-8(CAS DataBase Reference) |
京尼平苷又称栀子甙、京尼平甙，外观为棕色至白色结晶性粉末，气微，无苦味，是从茜草科植物栀子的干燥成熟果实中提取的一种环烯醚萜苷类化合物，具有显著的促进胆汁的分泌作用。并能降低血中胆红素，可促进血液中胆红素迅速排泄。
栀子苷对溶血性链球菌和皮肤真菌有抑制作用。有解热、镇痛、镇静、降压及止血作用。泻火除烦，清热利湿，凉血解毒，消肿止痛。主治热病心烦，躁扰不宁，高热烦躁，神昏谵语，黄疸尿赤，热淋涩痛，血热吐衄，目赤肿痛，火毒疮疡；外治扭挫伤痛。
Geniposide是Gardenia jasminoides Ellis果实分离得到的一种环烯醚萜苷类。Geniposide exhibits a variety of activities, such as on antithrombosis, anti-inflammation, anti-diabetes, anti-atherosclerosis, antidepression, healing Alzheimer’s disease (AD), anti-hypertension, toxicology, and untoward reaction are summarized. Geniposide markedly declines the production of IL-8, IL-1β and MCP-1 in OGD-induced brain microvascular endothelial cells, the expression of P2Y14 receptor is significantly down-regulated, the phosphorylation of RAF-1, MEK1/2, ERK1/2 are suppressed.
Geniposide (200 and 400 mg/kg) significantly decreases the blood glucose, insulin and TG levels in diabetic mice in a dose-dependent manner. This compound also decreases the expression of GP and G6Pase at mRNA and immunoreactive protein levels, as well as enzyme activity. Geniposide (20.0, 40.0, or 80 mg/kg) significantly reverses the excessive, alcohol-induced elevation in both serum ALT/AST and hepatic LPO levels. Geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons. Geniposide inhibits photochemistry-induced thromboembolism model in vivo . Geniposide are very effective depressants on NF-κB by interrupting IκB degradation.
药理药效:栀子苷具有缓泻、镇痛、利胆、抗炎、治疗软组织损伤以及抑制胃液分泌和降低胰淀粉酶等作用。
安全信息
| 安全说明 | 24/25 |
|---|---|
| WGK Germany | 3 |
| 海关编码 | 29389090 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0009 | 栀子苷 Geniposide | 24512-63-8 | 50mg | 500元 |
| 2024/01/25 | HY-N0009 | 栀子苷 Geniposide | 24512-63-8 | 10mM * 1mLin DMSO | 550元 |