ChemicalBook > Product Catalog >API >Antibiotics >Penicillins drugs >PIVAMPICILLIN

PIVAMPICILLIN

PIVAMPICILLIN Suppliers list
Company Name: Guangzhou PI PI Biotech Inc
Tel: ;
Email: sales@pipitech.com;87478684@qq.com
Products Intro: Product Name:Pivampicillin
CAS:33817-20-8
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:Chemical Formula: C22H29N3O6S, Exact Mass: 463.17771, Molecular Weight: 463.54900,(pivaloyloxy)methyl (2S,5R,6R)-6-((R)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Company Name: BOC Sciences
Tel: 1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Pivampicillin
CAS:33817-20-8
Purity:>95%
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel:
Email: 1017@dideu.com
Products Intro: Product Name:PivaMpicillin
CAS:33817-20-8
Purity:99% Package:1KG;1USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-89586680
Email: 1005@dideu.com
Products Intro: Product Name:PIVAMPICILLIN USP/EP/BP
CAS:33817-20-8
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Dideu Industries Group Limited
Tel: 029-88380327; 17691182729
Email: Service@dideu.com
Products Intro: Product Name:PIVAMPICILLIN USP/EP/BP
CAS:33817-20-8
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer

Lastest Price from PIVAMPICILLIN manufacturers

  • PIVAMPICILLIN USP/EP/BP
  • US $1.10 / g
  • 2021-06-28
  • CAS:33817-20-8
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
  • PivaMpicillin
  • US $1.00 / KG
  • 2020-05-12
  • CAS: 33817-20-8
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 20T
PIVAMPICILLIN Basic information
Product Name:PIVAMPICILLIN
Synonyms:4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(2-amino-2-phenylacetami;ampicillinpivaloyloxymethylester;hydroxymethylester,pivalate(ester),d-(-)-do)-3-dimethyl-7-oxo-;mk191;pivaloylampicillin;pivaloyloxymethylampicillinate;PIVAMPICILLIN;PIVAPICILLIN
CAS:33817-20-8
MF:C22H29N3O6S
MW:463.55
EINECS:251-688-6
Product Categories:
Mol File:33817-20-8.mol
PIVAMPICILLIN Structure
PIVAMPICILLIN Chemical Properties
Boiling point 679.0±55.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
solubility Practically insoluble in water, freely soluble in methanol, soluble in anhydrous ethanol. It dissolves in dilute acids.
pkapKa 7.0 (Uncertain)
Safety Information
MSDS Information
PIVAMPICILLIN Usage And Synthesis
DescriptionPivampicillin caused sensitization in 56 workers at a penicillin factory. Pivampicillin and pivmecillinam were responsible for contact dermatitis in pharmaceutical production workers. Ampicillin, mecillinam, penicillin V and penicillin G were also implicated in cross reactions.
Chemical PropertiesWhite or almost white, crystalline powder.
OriginatorMaxifen ,Sharp and Dohme, W. Germany ,1972
UsesAntibacterial.
Manufacturing Process(A) Pivaloyloxymethyl D(-)-α-azidobenzylpenicillinate: To a suspension of potassium D(-)α-azidobenzylpenicillinate (4.14 g) and potassium dicarbonate(1.5 g) in acetone (100 ml) and 10% aqueous sodium iodide (2 ml), chloromethyl pivalate (2.7 ml) was added and the mixture refluxed for 2 hours. After cooling, the suspension was filtered and the filtrate evaporated to dryness in vacuo. The remaining residue was washed repeatedly by decantation with petroleum ether to remove unreacted chloromethyl pivalate. The oily residue was taken up in ethyl acetate (100 ml), and the resulting solution washed with aqueous sodium bicarbonate and water, dried and evaporated in vacuo to yield the desired compound as a yellowish gum, which crystallized from ether, melting point 114°C to 115°C.
(B) Pivaloyloxymethyl D(-)-α-aminobenzylpenicillinate, hydrochloride: To a solution of pivaloyloxymethyl D(-)-α-azidobenzylpenicillinate (prepared as described above) in ethyl acetate (75 ml) a 0.2 M phosphate buffer (pH 2.2) (75 ml) and 10% palladium on carbon catalyst (4 g) were added, and the mixture was shaken in a hydrogen atmosphere for 2 hours at room temperature. The catalyst was filtered off, washed with ethyl acetate (25 ml) and phosphate buffer (25 ml), and the phases of the filtrate were separated. The aqueous phase was washed with ether, neutralized (pH 6.5 to 7.0) with aqueous sodium bicarbonate, and extracted with ethyl acetate (2 x 75 ml). To the combined extracts, water (75 ml) was added, and the pH adjusted to 2.5 with 1 N hydrochloric acid. The aqueous layer was separated, the organic phase extracted with water (25 ml), and the combined extracts were washed with ether, and freeze-dried. The desired compound was obtained as a colorless, amorphous powder.
The purity of the compound was determined iodometrically to be 91%. A crystalline hydrochloride was obtained from isopropanol with a melting point of 155°C to 156°C (dec.).
Therapeutic FunctionAntibacterial
Contact allergensPivampicillin is a prodrug of ampicillin. It caused sensitization in 56 workers at a penicillin factory. Pivampicillin and pivmecillinam were responsible for contact dermatitis in pharmaceutical production workers. Ampicillin, mecillinam or amdinocillin, penicillin V and penicillin G were also implicated in cross-reactions.
PIVAMPICILLIN Preparation Products And Raw materials
Raw materialsHydrogen-->Chloromethyl pivalate
Tag:PIVAMPICILLIN(33817-20-8) Related Product Information
Dicloxacillin sodium Penicillin G sodium salt Penicillin G Ampicillin Ampicillin Pivampicillin Ep 4-METHOXY-2-METHYL-2-BUTANETHIOL PENAMECILLIN pivalyloxymethyl butyrate PIVAMPICILLIN