188404-10-6
| 中文名称 | 188404-10-6 |
|---|---|
| 中文同义词 | ((5Z,8Z,11Z,14Z)-二十碳-5,8,11,14-四烯-1-基)氟磷酸甲酯;化合物 T15948;甲基花生四烯酸氟磷酸酯 |
| 英文名称 | MAFP |
| 英文同义词 | 5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER;(5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENYL-METHYL ESTER PHOSPHONOFLUORIDIC ACID;MAFP;MAPF;METHYL-5Z,8Z,11Z,14Z-EICOSATETRAENYL ESTER PHOSPHONOFLUORIDIC ACID METHYL ACETATE;METHYL ARACHIDONYL FLUOROPHOSPHONATE;METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester |
| CAS号 | 188404-10-6 |
| 分子式 | C21H36FO2P |
| 分子量 | 370.48 |
| EINECS号 | 201-185-2 |
| 相关类别 | Cannabinoid receptor;Fatty Acid Derivatives & Lipids, inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 188404-10-6.mol |
| 结构式 |  |
188404-10-6 性质
| 沸点 | 455.3±34.0 °C(Predicted) |
|---|---|
| 密度 | 0.960±0.06 g/cm3(Predicted) |
| RTECS号 | TA8108000 |
| 闪点 | -16 °C |
| 储存条件 | -70°C |
| 溶解度 | DMF：3mg/mL； DMSO：3mg/mL；乙醇：3.5mg/mL；乙醇:PBS (pH 7.2) 1:1: 0.5 mg/ml； PBS (7.2)：<1 mg/ml（胶体悬浮液 |
| 形态 | 醋酸甲酯溶液 |
| 敏感性 | Air Sensitive |
MAFP (Methyl Arachidonyl Fluorophosphonate) 是选择性，针对活性位点，不可逆的 cPLA2 和 iPLA2 抑制剂。 MAFP也是一种有效的不可逆的 anandamide amidase 抑制剂。
cPLA2, iPLA2, Anandamide amidase
MAFP inhibits iPLA2, in a concentration-dependent manner with an IC 50 of 5 μM after a 5 min preincubation at 40°C in P388D1 cells. cPLA, is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile. MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP demonstrates selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. MAFP displaces [ 3 H]CP-55940 binding to the CB1 cannabinoid receptor with an IC 50 of 20 nM vs 40 nM for anandamide.
安全信息
| 危险品标志 | F,Xi |
|---|---|
| 危险类别码 | 11-36-66-67 |
| 安全说明 | 16-26-29-33 |
| 危险品运输编号 | UN 1231 3/PG 2 |
| WGK Germany | 1 |
| 提供商 | 语言 |
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英文
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