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| | 3-(4-FLUOROBENZOYL)PROPIONIC ACID Basic information |
| | 3-(4-FLUOROBENZOYL)PROPIONIC ACID Chemical Properties |
| Melting point | 100-102 °C (lit.) | | Boiling point | 374.4±22.0 °C(Predicted) | | density | 1.2441 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | powder to crystal | | pka | 4.50±0.17(Predicted) | | color | White to Orange to Green | | Water Solubility | Insoluble in water. | | BRN | 958145 | | CAS DataBase Reference | 366-77-8(CAS DataBase Reference) |
| | 3-(4-FLUOROBENZOYL)PROPIONIC ACID Usage And Synthesis |
| Chemical Properties | beige granular powder | | Uses | 7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone. | | Definition | ChEBI: 4-(4-Fluorophenyl)-4-oxobutanoic acid is an aromatic ketone. | | General Description | 3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker. |
| | 3-(4-FLUOROBENZOYL)PROPIONIC ACID Preparation Products And Raw materials |
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