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Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:Anti-VinculinFITC antibody, Mouse monoclonal
Purity:monoclonal hVIN-1, purified from hybridoma cell culture Package:200μL Remarks:F7053
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| | Anti-VinculinFITC antibody, Mouse monoclonal Basic information |
| | Anti-VinculinFITC antibody, Mouse monoclonal Chemical Properties |
| | Anti-VinculinFITC antibody, Mouse monoclonal Usage And Synthesis |
| Uses | Monoclonal Anti-Vinculin-FITC antibody is suitable for immunofluorescence staining of fibroblasts cells to study the effects of nanofiber spatial organization on cell behaviors. It is also suitable for direct immunofluorescence at a dilution of 1:50 using methanol/acetone fixed cultured bovine MDBK cells. | | Biochem/physiol Actions | Vinculin is a cytoskeletal protein with molecular mass of ~116 kDa. Vinculin is closely associated with adhesive membrane areas, such as focal contacts, podosomes, or intercellular junctions of the zonula adherens type. It acts as a mediator in interactions of integrins and the actin cytoskeleton. It forms a bridge between integrins, receptors for ECM molecules on the cell surface and the F-actin cytoskeleton. It is associated with talin and α-actinin which directly connects with integrins. It has ability to bind α-catenin as well as the vasodilator stimulated phosphoprotein (VASP) in focal contact assembly. |
| | Anti-VinculinFITC antibody, Mouse monoclonal Preparation Products And Raw materials |
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