RNAIII-inhibiting peptide(TFA)
| 中文名称 | RNAIII-inhibiting peptide(TFA) |
|---|---|
| 中文同义词 | |
| 英文名称 | RNAIII-inhibiting peptide(TFA) |
| 英文同义词 | RNAIII-inhibiting peptide(TFA);RNAIII inhibiting peptide TFA,RNAIIIinhibiting peptide TFA |
| CAS号 | |
| 分子式 | C??H??F?N??O?? |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
RNAIII-inhibiting peptide(TFA) 性质
Staphylococcus aureus
RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus . RNAIII-inhibiting peptide (RIP) inhibits the synthesis of both RNAII and RNAIII, while RAP activates in wild type S. aureus cells. RNAIII-inhibiting peptide (5 μg/10 6 cells) potently reduces bacterial cell adhesion to HEp2 cells in the absence of serum, but with slight overall reduction the presence of serum. RNAIII-inhibiting peptide inhibits while RAP induces the phosphorylation of TRAP.
RNAIII-inhibiting peptide (20 mg/kg, i.v.) decreases lethality in mice challenged with S. aureus ATCC 25923, with the lethality rate of 70%, and when combined with cefazolin, imipenem, vancomycin, the rates are 20%, 15% and 10%. RNAIII-inhibiting peptide (20 mg/kg, i.v.) also causes decreased lethality in mice challenged with S. aureus Smith, with the lethality rate of 75%, and the lethality rate decreases to 30%, 10% and 10% when combined with cefazolin, imipenem, vancomycin.