TFLLR-NH2(TFA)
中文名称 | TFLLR-NH2(TFA) |
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中文同义词 | (S)-2-((S)-2-((2S,3R)-2-氨基-3-羟基丁酰胺基)-3-苯基丙酰胺基)-N-((S)-1-((S)-1-氨基-5-胍基-1-氧代戊-2-基)氨基)-4-甲基-1-氧代戊-2-基)-4-甲基戊酰胺 2,2,2-三氟乙酸盐;激动剂TFLLR-NH2 |
英文名称 | TFLLR-NH2(TFA) |
英文同义词 | TFLLR-NH2(TFA);197794-83-5 (Thr1)-TRAP-5 amide;(S)-2-((S)-2-((2S,3R)-2-Amino-3-hydroxybutanamido)-3-phenylpropanamido)-N-((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide 2,2,2-trifluoroacetate |
CAS号 | 1313730-19-6 |
分子式 | C33H54F3N9O8 |
分子量 | 761.85 |
EINECS号 | |
相关类别 | 多肽;多肽;目录多肽 |
Mol文件 | 1313730-19-6.mol |
结构式 |
TFLLR-NH2(TFA) 性质
储存条件 | Store at -20°C |
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溶解度 | 水:100mg/mL(131.26mM);二甲基亚砜:100 mg/mL(131.26 mM) |
序列 | H-Thr-Phe-Leu-Leu-Arg-NH2 |
EC50: 1.9 μM (PAR1)
PAR1 agonists stimulate concentration-dependent increases in [Ca 2+ ]i and in the proportions of neurones. The maximal increase in [Ca 2+ ]i above basal is detected in response to 10 μm TF-NH2 (peak 196.5±20.4 nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.
Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1 h and completely by 5 h. In wild-type but not PAR1 −/− mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-P0226A | 1313730-19-6 TFLLR-NH2(TFA) | 1313730-19-6 | 1mg | 1800元 |
2024/01/25 | HY-P0226A | 1313730-19-6 TFLLR-NH2(TFA) | 1313730-19-6 | 5mg | 7200元 |