|
|
| Product Name: | Methylprednisolone hemisuccinate | | Synonyms: | 6-alpha-Methyl Isomer of Methylhydrocortisone 21-Hydrogen Succinate;11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-succinate;6a- methyl prednisolone acetate half Kohaku;4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-(hy;4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-suc;6-methylprednisolonehemisuccinate;Methylprednisolone sucsinate;Methylprednisolone Hemisuccinate (200 mg) | | CAS: | 2921-57-5 | | MF: | C26H34O8 | | MW: | 474.54 | | EINECS: | 220-863-9 | | Product Categories: | Steroid and Hormone;Steroids | | Mol File: | 2921-57-5.mol |  |
| | Methylprednisolone hemisuccinate Chemical Properties |
| Melting point | >230°C (dec.) | | Boiling point | 689.6±55.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Practically insoluble in water, slightly soluble in acetone and in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides. | | pka | 4.29±0.17(Predicted) | | color | White to Off-White | | LogP | 2.69 | | CAS DataBase Reference | 2921-57-5(CAS DataBase Reference) |
| | Methylprednisolone hemisuccinate Usage And Synthesis |
| Description | Methylprednisolone hemisuccinate is a glucocorticoid used to treat severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal disorders, and endocrine disorders, among others. | | Synthesis | Add 6L of dimethyl sulfoxide and 1kg of succinic anhydride in the reaction kettle, stir and dissolve at 25°C, add 0.8L of triethylamine, and stir for 10 minutes; add 1kg of methylprednisolone again, react at 30°C for 3 hours, add 10% hydrochloric acid water Terminate the reaction, separate 40 L of water, and stir for 30 minutes; filter and wash with water to obtain the crude product; the crude product is dissolved in 30 times of methanol temperature, and activated carbon is decolorized to obtain methylprednisolone succinate; the yield is 119%, and the content is 99.3%. | | Chemical Properties | White or almost white, hygroscopic powder. | | Uses | Glucocorticoid. | | Uses | 6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis. | | Definition | ChEBI: Methylprednisolone succinate is a corticosteroid hormone and a hemisuccinate. | | Brand name | A-Methapred (Abbott);
A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn). |
| | Methylprednisolone hemisuccinate Preparation Products And Raw materials |
|