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Raspberry Ketone

Raspberry Ketone Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Products Intro: Product Name:4-(4-Hydroxyphenyl)-2-butanone
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:5471-51-2
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Products Intro: Product Name:4-(4-Hydroxyphenyl)-2-butanone fandachem
Purity:As coa Package:As request Remarks:5471-51-2
Company Name: Rixing Chemical CO.,LTD
Tel: 13237129059
Products Intro: Product Name:Raspberry Ketone
Purity:0.98 Package:1gram;10g;100g;1kg/foilbag;5kg/drum;25kg/drum
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Products Intro: CAS:5471-51-2
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified

Lastest Price from Raspberry Ketone manufacturers

  • Raspberry Ketone
  • US $30.00 / KG
  • 2021-07-13
  • CAS:5471-51-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1 ton
  • Raspberry Ketone
  • US $15.00-10.00 / KG
  • 2021-07-13
  • CAS:5471-51-2
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton

Related articles

Raspberry Ketone Basic information
Chemical properties Uses Production method
Product Name:Raspberry Ketone
Synonyms:4-(4-Hydroxyphenyl)-2-butanone 5471-51-2;Natural Raspberry Ketone;Dobutamine EP Impurity B;Dobutamine Hydrochloride Impurit Ⅰ:4-(4-Hydroxyphenyl)-2-butanone;4-p-Hydroxylphenyl)-2-butone;Raspberry keton;RASPBERRY KETONE;RASBERRY KETONE
Product Categories:Aromatic Ketones (substituted);Food and Feed Additive;Aromatics;Herb extract
Mol File:5471-51-2.mol
Raspberry Ketone Structure
Raspberry Ketone Chemical Properties
Melting point 81-85 °C (lit.)
Boiling point 200°C
density 1.0326 (rough estimate)
refractive index 1.5250 (estimate)
storage temp. Refrigerator
solubility 95% ethanol: soluble50mg/mL, clear to slightly hazy, colorless to faint yellow or tan
form Liquid
color Clear colorless
Water Solubility Insoluble in water.
JECFA Number728
BRN 776080
CAS DataBase Reference5471-51-2(CAS DataBase Reference)
NIST Chemistry Reference2-Butanone, 4-(4-hydroxyphenyl)-(5471-51-2)
EPA Substance Registry System2-Butanone, 4-(4-hydroxyphenyl)- (5471-51-2)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22
Safety Statements 26-36/37/39-36
WGK Germany 2
RTECS EL8925000
Hazard Note Irritant
HS Code 29145011
MSDS Information
Frambinone English
SigmaAldrich English
ACROS English
ALFA English
Raspberry Ketone Usage And Synthesis
Chemical propertiesIt appears as white needle crystal or granular solid, exhibiting raspberry aroma and fruit aroma. The melting point temperature is 82~83 °C. It is insoluble in water and oil, being soluble in alcohol, ether and volatile oil.
The natural products exist in raspberry (raspberry) and so on.
Uses1. Raspberry Ketone is used in the preparation of food spices with sweetening effect, can also be used for cosmetics and soap flavor.
2. Raspberry Ketone is widely used in strawberry, raspberry, pineapple, peaches and other food flavors, usually used as a fixing agent in the fruity flavor. In daily flavor, it can be used in formulations such as jasmine, gardenia flowers and tuberose. As a modifier, it can be used in jasmine, gardenia, tuberose and other fragrant daily flavor. In food flavors, it is mostly used for strawberries, pineapple, peaches, plums, mayberry and other fragrance. In medicine, it is mostly used as intermediates.
Production method3.5mol 15% sodium hydroxide is first added to the reactor, and 2 mol of acetone and 1mol of p-hydroxybenzaldehyde are added dropwise under stirring. The temperature is controlled between 20 and 30 DEG C, and the stirring reaction is continued for 20 hours. The solid sodium salt of 4-p-hydroxyphenylbutene-3-ketone-2 was obtained after filtering, further dissolved in water, and then acidified with hydrochloric acid to precipitate 4-p-hydroxyphenylbutene-3-ketone-2, further filter and dry for further application.
The autoclave was supplied with 100 g of the intermediate and 5 g of the nickel catalyst, and the atmosphere was replaced with hydrogen. The mixture was heated to 120-140 °C and reacted at a pressure of 0.98 MPa for 1.5 h. After cooling, the catalyst was filtered off, the raspberry ketone content was 89% and the hydrogenation yield was 92%. The crude product above is subject to vacuum distillation once with further recrystallization of 1-2 times getting white crystals with the melting point of 82 ° C.
Phenol route
94g phenol and 85% phosphoric acid mixed catalyst were added into the reactor, 70g methyl vinyl ketone was added dropwise in 40min, the temperature was maintained at 15-20 ℃, and the reaction was stirred for 4h. After completion of the reaction, the reaction mixture was washed with water until neutral, and 63 g of phenol was distilled off under reduced pressure to obtain 25 g of a product having a melting point of 81.5 to 82.5 ° C and a yield of 80%.
It is obtained through the condensation between hydroxybenzaldehyde and acetone and further hydrogenation.
It is obtained through the condensation between the ketone acid and phenol.
Description4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves odor. May be prepared by catalytic hydrogenation of phydroxy-benzylidene acetone in the presence of platinum black in ether or methanol or in the presence of palladium absorbed on charcoal.
Chemical Properties4-(p-Hydroxyphenyl)-2-butanone has a sweet, fruity, raspberry preserves–type odor.
Chemical Properties4-(4-Hydroxyphenyl)-2-butanone is a highly characteristic component of raspberry aroma. It forms colorless crystals (mp 82–83°C) with a sweet, fruity odor strongly reminiscent of raspberries. Raspberry ketone is prepared by alkali-catalyzed condensation of the alkali salt of 4-hydroxybenzaldehyde and acetone, followed by selective hydrogenation of the double bond in the resulting 4-hydroxybenzalacetone. Other syntheses start from phenol, which is converted into 4-(4-hydroxyphenyl)-2-butanone with methyl vinyl ketone or with 4-hydroxy-2-butanone.
Chemical Propertieswhite to slightly yellow powder or needles
OccurrenceReported found European cranberry, raspberry, blackberry, loganberry and sea buckthorn (Hippophae rhamnoides L.).
UsesThe primary aroma compound of red raspberries, used in perfume compositions, shampoos, cosmetics and as a food additive. Also an impurity in the synthesis of Dobutamine (D494445).
UsesIntermediates of Liquid Crystals
DefinitionChEBI: A ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at position 4 by a hydroxy group. It is found in a variety of fruits including raspberries, blackberries and cranberries, and is used in perfumery and cosmetics.
Taste threshold valuesTaste characteristics at 40 ppm: fruity, jamy, berry, raspberry, and blueberry with seedy, cotton candy nuances
Synthesis Reference(s)The Journal of Organic Chemistry, 41, p. 1206, 1976 DOI: 10.1021/jo00869a026
Synthetic Communications, 19, p. 1109, 1989 DOI: 10.1080/00397918908051034
Safety ProfilePoison by intraperitoneal route. Moderately toxic by ingestion. Flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
Raspberry Ketone Preparation Products And Raw materials
Raw materialsEthanol-->Acetone-->p-Hydroxybenzaldehyde-->Methyl vinyl ketone-->4-Phenyl-1-butene-->4,4'-Carbonyldiphthalic acid
Tag:Raspberry Ketone(5471-51-2) Related Product Information
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