3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮
| 中文名称 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 |
|---|---|
| 中文同义词 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮;化合物 T9147 |
| 英文名称 | FEN1 Inhibitor C3 |
| 英文同义词 | FEN1 Inhibitor C3;FEN1-IN-3;2,4(1H,3H)-Quinazolinedione, 3-hydroxy-1-(4-methoxyphenyl)-;3-Hydroxy-1-(4-methoxyphenyl)quinazoline-2,4(1H,3H)-dione |
| CAS号 | 2109805-87-8 |
| 分子式 | C15H12N2O4 |
| 分子量 | 284.27 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2109805-87-8.mol |
| 结构式 |  |
3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 性质
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：250 mg/mL（879.45 mM） |
FEN1-IN-3 (Compound 4) 是一种人类皮瓣内切核酸酶-1 (hFEN1) 抑制剂。FEN1-IN-3 可使 hFEN1 稳定化，EC50 为 6.8 μM。
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a , both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-136484 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 FEN1-IN-3 | 2109805-87-8 | 5mg | 790元 |
| 2024/04/30 | HY-136484 | 3-羟基-1-(4-甲氧基苯基)喹唑啉-2,4(1H,3H)-二酮 FEN1-IN-3 | 2109805-87-8 | 10mM * 1mLin DMSO | 869元 |