TMP920
中文名称 | TMP920 |
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中文同义词 | TMP920;化合物 T17108 |
英文名称 | TMP920 |
英文同义词 | TMP920;Benzeneacetamide, 4-[(3,5-dimethyl-4-isoxazolyl)methoxy]-N-[(2,4-dimethylphenyl)phenylmethyl]- |
CAS号 | 1421837-45-7 |
分子式 | C29H30N2O3 |
分子量 | 454.56 |
EINECS号 | |
相关类别 | |
Mol文件 | 1421837-45-7.mol |
结构式 |
TMP920 性质
沸点 | 693.8±55.0 °C(Predicted) |
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密度 | 1.150±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:62.5 mg/mL(137.50 mM) |
酸度系数(pKa) | 14.55±0.46(Predicted) |
IC50: 0.03 μM (RORγt)
TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4
+
T cells.
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro.
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro.
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets.
TMP920 significantly reduces RORγt-DNA interactions.
Cell Cytotoxicity Assay
Cell Line: | Naïve CD4 + T cells |
Concentration: | 0.09-30 μM |
Incubation Time: | 48 hours |
Result: | Has toxic effects on cell growth at >10 μM. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-117819 | TMP920 | 1 mg | 863元 | |
2024/01/25 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 5mg | 1900元 |