8-OH-DPAT
| 中文名称 | 8-OH-DPAT |
|---|---|
| 中文同义词 | 化合物8-OH-DPAT;8-羟基-DPAT;8-羟基四氢萘;8-OH-DPAT (8-Hydroxy-DPAT) ,S8447;8-羟基-DPAT分析标准品 |
| 英文名称 | S(-)-8-hydroxy-dpat hydrobromide partial 5-HT1A secrot |
| 英文同义词 | (+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide;7-(dipropylamino)tetralin-1-ol;8-Hydroxy-2-(di-n-propylamino)tetralin;2-(Dipropylamino)tetralin-8-ol;2-(N,N-Dipropylamino)-1,2,3,4-tetrahydronaphthalen-8-ol;5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol;8-Hydroxy-2-(dipropylamino)-1,2,3,4-tetrahydronaphthalene;3-(dipropylamino)tetralin-5-ol |
| CAS号 | 78950-78-4 |
| 分子式 | C16H25NO |
| 分子量 | 247.38 |
| EINECS号 | |
| 相关类别 | Serotonin receptor |
| Mol文件 | 78950-78-4.mol |
| 结构式 |  |
8-OH-DPAT 性质
| 沸点 | 372.5±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.03±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 150mg/ml DMSO 溶液 |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.54±0.40(Predicted) |
| 颜色 | 白色 |
| 旋光度 (Optical Rotation) | [α]25/D 67.8° in methanol(lit.) |
| InChI | 1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m0./s1 |
| InChIKey | BATPBOZTBNNDLN-UQKRIMTDSA-N |
| SMILES | Br.CCCN(CCC)[C@H]1CCc2cccc(O)c2C1 |
|
5-HT 1A Receptor 8.19 (pIC 50 ) |
5-HT 7 Receptor 466 nM (Ki) |
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC 50 of 8.19 for 5-HT1A; weakly binds to 5-HT1B (pIC 50 , 5.42), 5-HT (pIC 50 <5). 8-OH-DPAT has high affinity at 5-HT7 with a K i of 466 nM, and does not bind to 5-HT6 or 5-HT4.
8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice.
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-112061R | 8-OH-DPAT 8-OH-DPAT (Standard) | 78950-78-4 | 5 mg | 1280元 |
| 2026/09/15 | HY-112061R | 8-OH-DPAT 8-OH-DPAT (Standard) | 78950-78-4 | 10 mg | 2050元 |