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Postion:Product Catalog >API>Hormones and the Endocrine System>Estrogen and progestin drugs>Estradiol valerate
Estradiol valerate
  • Estradiol valerate
  • Estradiol valerate
  • Estradiol valerate
  • Estradiol valerate
  • Estradiol valerate

Estradiol valerate NEW

Price $70
Package 1KG
Min. Order: 1KG
Supply Ability: 9000kg/per week
Update Time: 2023-12-05

Product Details

Product Name: Estradiol valerate CAS No.: 979-32-8
EC-No.: 213-559-2 Min. Order: 1KG
Purity: 99% Supply Ability: 9000kg/per week
Release date: 2023/12/05

Product Description


Product NameEstradiol valerate
CAS979-32-8
MFC23H32O3
MW356.5
EINECS213-559-2
Melting point144°C
Boiling point438.83°C
Density1.1024/cm3
Estradiol valerate as a valerate of natural estradiol, estradiol valerate has the pharmacological effect of estrogen, can promote and regulate the normal development of female genital canal and secondary sexual characteristics, and participate in the regulation of ovarian axis function. Bioactivity Estradiolvalerate is a synthetic ester used to treat menopausal symptoms and hormone deficiencies. In vitro studies with TargetValueER enhanced phosphorylation at Ser225 in MCF-7 cells showed that Estradiol(10nM) rapidly activated SphK1, a sphingosine kinase isoenzyme. Estradiol(20nM) stimulated the rapid release of sphingosine 1-phosphate (S1P) and dihydros1p from MCF-7 cells. SphK1 and estrogen receptors are the main causes of S1P and dihydro-S1P formation. Downregulation of ABCC1 or ABCG2 with siRNAs or pharmacological inhibitors reduced Estradiol(10nM) -mediated S1P and dihydros1P release from MCF-7 cells. Estradiol(10nM) inhibits the expression of miR-21 in estrogen receptor-α-mediated MCF-7 human breast cancer cells. Estradiol(10nM) activated the activity of several miR-21 target gene receptors in MCF-7 cells by inhibiting the expression of miR-21. Estradiol(10nM) increased the expression of endogenous miR-21 target genes in MCF-7 cells at the protein level, but did not affect the RNA level expression. In vivo study Estradiol(80μg/kg/day,s.c.) significantly reduced the absolute number of total peritoneal cells and macrophages in ovariectomized C57BL/6J mice, characterized by double F4/80- and CD11b- positive staining. In ovariectomized C57BL/6J mice, Estradiol(80μg/kg/day,s.c.) enhanced the expression of proinflammatory cytokines in LPs-induced TGC-induced macrophages by inhibiting PI3K activity. The pro-inflammatory effect of Estradiol is eliminated by down-regulating the activity of estrogen-receptor α in thioglycolate-induced macrophages. Use for amenorrhea, menopause syndrome, reduce milk secretion, prostate cancer and so on. Use for the treatment of amenorrhea, menopause syndrome, reduce milk secretion, prostate cancer and so on.

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Packaging & Shipping


                                   Shipping Terms                                                   

              By Express

                     By Air

                  By Sea

      Suitable for under 50kg

      Fast: 3-7 days

 

      High cost

      Door to door service,

      easy to pick up the goods

      Suitable for more than 50kg

      Fast: 3-7 days

      High cost

      Port to port, 

      professional broker needed

    Suitable for more than 500kg

    Slow: 7-45 days

    Low cost

    Port to port, 

    professional broker needed

 

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Our Services

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Company Information


 Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise,  The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market.  Welcome domestic and foreign customers to negotiate.

 

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Company Profile Introduction

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erin
18031140164
erin@hbldbiotech.com