Sorafenib tosylate

CAS 284461-73-0 Sorafenib tosylate supplier in China

1. details 

 Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that Sorafenib induces c-Raf phosphorylation at both Ser-43 and Ser-259. When combined with vitamin K1 phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit.

Functions:

Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that Sorafenib induces c-Raf phosphorylation at both Ser-43 and Ser-259. When combined with vitamin K1 phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit.

Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine. Sorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

2. pictures 

other hotselling products 

Package and shipping 

package: small order in sealed foil bag 

big order in 25kg paper drum or carton box 

shipping : Parcels will be no encounter customs issues such as Mexico ,Spain, UK, Netherlands, USA, Ireland, France, Germany, Brazil, Italy, and many European countries
WE HAVE SPECIAL SHIPPING WAY DDP delivery to your door ,safe and fast 

by express like fedex ,TNT, DHL 

by air to the aiport 

by sea to the seaport 

About our company 

Hebei Crovell Biotech Co,.LTD. is the leading manufacturer for cosmetic materials in China.

Which located in Shijiazhuang, Hebei Province.

We are specialized in pharmaceutical intermediates, veterinary drug intermediates and dyes intermediates,

After ten years development, Hebei Crovell Biotech Co,.LTD. has become a Diversified development company, not only involves in chemicals, but also real estate, clothes, agricultural products and so on.

So far, Hebei Crovell Biotech Co,.LTD. has business in more than 35 countries, most big customers come from Europe and America, because among the suppliers in China, Crovell can always make the product quality best, some of the products from Crovell can reach the purity of 99.9+, such as carbomer. This is the important reason for customers who choosing Crovell.

In future, Hebei Crovell Biotech Co,.LTD. must become to a more important trade bridge for China and foreign countries especially in pharmaceutical industries

FAQ 

Q: How to start orders or make payments?

A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and
we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q: What's your MOQ?

A:For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts
from 100g and 1kg.

Q: Is there a discount?

A: Yes, for larger quantity, we always support with better price.

Q:How do you treat quality complaint?

First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we
will send you free goods for replacement or refund your loss.

Q:How to contact us ?
You can choose your interested products and send inquiry to us.You can dial our telephone directly, you will get our reply.