Heparin sodium NEW

Heparin sodium is an anticoagulant and sticky polysaccharide substance. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. In human body, it is secreted by mast cells and naturally exists in blood. Heparin sodium can prevent platelet aggregation and destruction, inhibit the transformation of fibrinogen into fibrin monomer, inhibit the formation of thrombin and fight against the formed thrombin, prevent the transformation of prothrombin into thrombin and the effect of antithrombin. Heparin sodium can delay or prevent blood clotting in vivo and in vitro. The mechanism of its action is very complex, and it affects many links in the process of coagulation. Its role is: (1) inhibit the formation and function of thromboplastin, so as to prevent prothrombin into thrombin; (2) It can inhibit thrombin and other clotting factors in high concentration fashion, and prevent fibrinogen from becoming fibrin; (3) can prevent platelet agglutination and destruction. In addition, the anticoagulant effect of heparin sodium is related to the negatively charged sulfate in its molecules, and the positively charged alkaline substances such as protamine or toluidine blue can neutralize its negative charge, so it can inhibit its anticoagulant effect. Because heparin can activate and release lipoprotein esterase in the body, hydrolyze the triglyceride and low-density lipoprotein of chylomicron, it also has the effect of lowering blood lipid.

Application:

1. Prevent thrombosis and embolism, such as deep venous thrombosis, myocardial infarction, pulmonary embolism, thrombophlebitis and postoperative thrombosis, etc.

2. Treat disseminated intravascular coagulation (DIC) caused by various causes, such as bacterial sepsis, early placental dissection, and DIC caused by lysis of malignant tumor cells, except DIC caused by snakebite.Early application prevents the depletion of fibrinogen and other clotting factors.

3. Other anticoagulants in vivo and in vitro, such as cardiac catheterization, cardiopulmonary bypass, hemodialysis, etc .