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Postion:Product Catalog >API>Nervous system drugs>Antiepileptic and anticonvulsant> Pregabalin


$70.00 / 1KG

  • 1KG
Min. Order: 2KG
Purity: 99%
Cas No.: 148553-50-8
Supply Ability: >1000kg
  • Product Name: Pregabalin
  • CAS No.:148553-50-8
  • EC-No.:200-002-5
  • Min. Order:2KG
  • Purity:99%
  • Supply Ability:>1000kg
  • Release date:2021/08/10
Product Advantage
Pregabalin Basic information
Description Generic formulation Indications Dose titration Plasma levels monitoring Antiepileptic drus and therapeutic drugs for neuropathic pain Cautions Adverse effects Interactions Special populations Behavioural and cognitive effects in patients with epilepsy Psychiatric use
Product Name:Pregabalin
Synonyms:3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;(3S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;PREGABALIN;Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid;PREDNISOLONESODIUMPHOSPHATE;(R)-Pregabalin;(S)-Pregabalin
Product Categories:Miscellaneous Biochemicals;APIs;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;API;Pfizer compounds;LYRICA;pharmaceutical
Mol File:148553-50-8.mol
Pregabalin Structure

Pregabalin Chemical PropertiesMelting point 194-196°Calpha D23 +10.52° (c = 1.06 in water)Boiling point 274.0±23.0 °C(Predicted)density 0.997±0.06 g/cm3(Predicted)Fp 9℃storage temp. Store at RTsolubility deionized water: ≥10mg/mLpka4.23±0.10(Predicted)form white powderInChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-NCAS DataBase Reference148553-50-8(CAS DataBase Reference)

Safety InformationHazard Codes Xn,T,FRisk Statements 63-48/22-39/23/24/25-23/24/25-11Safety Statements 22-36/37-45-16-7RIDADR UN1230 - class 3 - PG 2 - Methanol, solutionWGK Germany 3HS Code 29224999Hazardous Substances Data148553-50-8(Hazardous Substances Data)
MSDS Information

Pregabalin Usage And SynthesisDescriptionPregabalin is a second- generation antiepileptic drug (AED) known with the proprietary brand name of Lyrica® (Pfizer, Tadworth) in the UK and USA (Pfizer, New York, NY).Generic formulationMHRA/ CHM advice to minimize risk when switching patients with epilepsy between different manufacturers’ products (including generic products):
  • It is usually unnecessary to ensure that patients are maintained on a specific manufacturer’s product unless there are specific concerns, such as patient anxiety and risk of confusion/ dosing error.

Adjunctive therapy of focal seizures with and without secondary generalization.

Recommendations summarized from NICE (2012)
  • Seizure types—on referral to tertiary care (focal seizures), contraindicated (generalized tonic- clonic seizures, tonic/ atonic seizures, absence seizures, myoclonic seizures).

  • Epilepsy types—on referral to tertiary care (benign epilepsy with centrotemporal spikes, panayiotopoulos syndrome, late- onset childhood occipital epilepsy), contraindicated (absence syndromes, idiopathic generalized epilepsy, juvenile myoclonic epilepsy, Dravet syndrome, Lennox– Gastaut syndrome).

Generalized anxiety disorder.

Peripheral and central neuropathic pain.
Dose titration
  • Epilepsy— adjunctive therapy: 25 mg bd for 7 days, to be increased by 50 mg every 7days; usual maintenance 300 mg daily, divided into 2 or 3 doses (max. 600 mg daily, divided into 2 or 3 doses).

  • Generalized anxiety disorder: 150 mg daily, divided into 2 or 3 doses, for 7 days, to be increased by 150 mg every 7 days (max. 600 mg daily, divided into 2 or 3 doses).

If stopping pregabalin, it is recommended to taper over at least 1 week to avoid abrupt withdrawal.
Plasma levels monitoringPregabalin pharmacokinetics are linear over the recommended daily dose range; inter- subject pharmacokinetic variability for pregabalin is low (<20%) and multiple dose pharmacokinetics are predictable from single- dose data. Therefore, there is no need for routine monitoring of plasma concentrations of pregabalin.
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