7α,25-Dihydroxycholesterol NEW
| Price | $253 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: 7α,25-Dihydroxycholesterol | CAS No.: 64907-22-8 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | 7α,25-Dihydroxycholesterol |
| Description | 7α,25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist, as well as an endogenous ligand, of the orphan GPCR receptor EBI2 (GPR183). It serves as a chemokine directing the migration of B cells, T cells, and dendritic cells and exhibits high potency in activating EBI2 (EC50=140 pM; Kd=450 pM) [1][2]. |
| In vitro | 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM in vitro. However, it had no effect on EBI2-deficient cells[1]. |
| In vivo | In vivo, B cells lacking EBI2 or normal B cells rendered insensitive through pre-treatment with 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) display decreased migration to spleen follicular regions[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1 mg/mL (2.39 mM), Sonication is recommended. |
| Keywords | response | receptor | oxysterols | migration | ligand | Inhibitor | inhibit | immune | Human Endogenous Metabolite | GPR183 | GPCR | EndogenousMetabolite | Endogenous Metabolite | endogenous | EBI2/GPR183 | EBI2 | cells | 7α,25-Dihydroxycholesterol | 7α,25Dihydroxycholesterol | 7α,25 Dihydroxycholesterol | 7alpha,25-OHC | 7alpha,25-Dihydroxycholesterol | 7a,25-OHC | 7a,25-Dihydroxycholesterol |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Oleamide | Glycerol | Thymidine | Naringin | L-Ascorbic acid sodium salt | 3-Indoleacetic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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