Alpelisib hydrochloride NEW
| Price | $1970 | $2580 | $3400 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Alpelisib hydrochloride | CAS No.: 1584128-91-5 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Alpelisib hydrochloride |
| Description | Alpelisib hydrochloride (BYL-719 hydrochloride) exhibits anticancer properties[1][2]. As a potent and selective PI3Kα inhibitor with high oral bioavailability, it has IC50 values of 5 nM for p110α, 250 nM for p110γ, 290 nM for p110δ, and 1200 nM for p110β, indicating its efficacy in targeting enzymes involved in cancer cell proliferation. |
| In vitro | Alpelisib (BYL-719) potently inhibits the two most common PIK3CA somatic mutations (H1047R, E545K; IC50s~4 nM) and significantly alters the distribution of cell cycle phases. At 25 μM for 18 hours, it induces a G0/G1 phase cell cycle arrest in human and murine osteosarcoma cell lines[3]. Additionally, Alpelisib (0-50 μM; 72 hours) inhibits the cell growth of osteosarcoma cell lines MG63, HOS, POS-1, and MOS-J in a dose-dependent manner[3]. In cells transformed with PI3Kα, it potently inhibits Akt phosphorylation (IC50=74±15 nM) and shows significantly reduced inhibitory activity in PI3Kβ or PI3Kδ isoform-transformed cells (≥15-fold compared with PI3Kα)[2]. |
| In vivo | Alpelisib has moderate terminal elimination half-life (t1/2=2.9±0.2 h) for rat (1 mg/kg, iv)[1]. Alpelisib (BYL-719) (12.5 mg/kg and 50 mg/kg for C57Bl/6J mice; 50 mg/kg for female Rj:NMRI-nude mice; oral administration; daily) significantly reduces tumor volumes and deposition of ectopic bone matrix[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Alpelisib hydrochloride | BYL-719 Hydrochloride | Alpelisib Hydrochloride | BYL 719 Hydrochloride | BYL719 Hydrochloride |
| Inhibitors Related | Musk ketone | Myricetin | Erucic acid | 4-Methylbenzylidene camphor | (±)-α-Bisabolol | Berberine hydrogen sulphate | Isoprenaline hydrochloride | Thymoquinone | Quercetin | Inavolisib | Berberine sulfate | Apilimod |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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