Amiodarone hydrochloride NEW
| Price | $36 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-12-02 |
Product Details
| Product Name: Amiodarone hydrochloride | CAS No.: 19774-82-4 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2025/12/02 |
Product Introduction
Bioactivity
| Name | Amiodarone hydrochloride |
| Description | Amiodarone hydrochloride is an anti-anginal agent and a class III antiarrhythmic drug that inhibits potassium channels (including wild-type hERG channels and their tail currents, with an IC₅₀ of approximately 45 nM) as well as voltage-gated sodium channels. This leads to prolonged action potential duration in ventricular and atrial myocytes, resulting in reduced heart rate and vascular resistance. It activates ERK1/2 and p38 MAPK signaling pathways in fibroblasts, promoting cell proliferation and myofibroblast differentiation. Amiodarone hydrochloride is widely used in the study of supraventricular and ventricular arrhythmias and can also be used to establish pulmonary fibrosis animal models. |
| In vitro | Amiodarone (AM) inhibits the intracellular conversion from thyroxine (T4) to triiodothyronine (T3) via 5'-deiodination (5'DI) without affecting the intracellular conversion from T4 to reverse T3 (rT3).1.25-25 mg/kg Amiodarone in the AV node and in anaesthetized dogs resulted in a decrease in sinus rate, a prolongation of the AV node effective and functional occlusion of the AV node, as well as frequency-dependent conduction delays. 50 mg/kg daily for 3-4 weeks Amiodarone in rabbit ventricular myocytes resulted in a significant reduction in iK and ito current densities without affecting ICA and IK1 densities. |
| In vivo | Amiodarone penetrates deeply into the lipid matrix of the membrane and is released very slowly from cardiac tissue during washout.Amiodarone inhibits fast sodium channels as well as slow calcium channels.Amiodarone also has non-competitive antiarrhythmic effects and regulates thyroid function and phospholipid metabolism.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells.44-88 μM Amiodarone inhibits Vmax of guinea pig papillary muscle without affecting normal hematopoietic stem cells. Amiodarone inhibits Vmax in papillary muscle without affecting the resting membrane potential, and this Vmax inhibition is potentiated in a frequency- or use-dependent manner as is the case with class I antiarrhythmic drugs.50-88 μM Amiodarone inhibits depolarization-induced spontaneous action potentials (aberrant automaticity) in ventricular myocardium and Purkinje fibers.50-88 μM Amiodarone inhibits depolarization induced action potentials (aberrant automaticity) in human ventricular muscle. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.47 mM), Sonication is recommended. DMSO : 7.5 mg/mL (11 mM), Sonication is recommended. |
| Keywords | β-adrenergic receptor | ventricular | tail | supraventricular | PotassiumChannel | Potassium Channel | benzofuran | Autophagy | ATP-sensitive potassium (KATP) channels | arrhythmias | antiarrhythmic | Amiodarone | Amiodar | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Alginic acid | Gefitinib |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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