Amodiaquine hydrochloride NEW
| Price | Get Latest Price |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: Amodiaquine hydrochloride | CAS No.: 69-44-3 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | Amodiaquine hydrochloride |
| Description | Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, is an antimalarial agent that also acts as a potent oral histamine N-methyltransferase inhibitor with a K i value of 18.6 nM. Additionally, it functions as a Nurr1 agonist, targeting the Nurr1-LBD (ligand binding domain) with an EC 50 of approximately 20 μM, demonstrating anti-inflammatory effects [1] [2] [3] [4] [5]. |
| In vitro | Amodiaquine treatment ranging from 10-20 μM for 4 hours significantly reduces the expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α, and iNOS) induced by LPS in a dose-dependent manner. Additionally, at a concentration of 5 μM over 24 hours, Amodiaquine markedly diminishes 6-OHDA-induced cell death in primary dopamine neurons, as evidenced by the preservation of TH+ neuron numbers and dopamine uptake. This neuroprotective effect is corroborated in rat PC12 cells. RT-PCR results from primary microglia treated with 10 μM, 15 μM, and 20 μM Amodiaquine for 4 hours further confirm the suppression of LPS-induced proinflammatory cytokine expression, demonstrating Amodiaquine’s potent anti-inflammatory and neuroprotective activities. |
| In vivo | Amodiaquine administration (40 mg/kg; intraperitoneal injection; daily for 3 days) in male ICR mice aged 8-10 weeks with induced intracerebral hemorrhage (ICH) significantly diminished the activation of perihematomal microglia/macrophages and astrocytes. Furthermore, the treatment effectively suppressed ICH-induced mRNA expression levels of IL-1β, CCL2, and CXCL2, concurrently ameliorating the motor dysfunction observed in these animals. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Amodiaquine hydrochloride | Amodiaquine Hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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