Caldaret NEW
| Price | $521 | $1230 | $1610 |
| Package | 5mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: Caldaret | CAS No.: 133804-44-1 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | Caldaret |
| Description | Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. |
| In vitro | Caldaret resume Ca2+-ATPase activity of the sarcoplasmic reticulum isolated from the myocardium acutely exposed to ischemia and reperfusion in vitro [2]. |
| In vivo | Caldaret (MCC-135) has beneficial effects in heart failure. In diabetic rats, Caldaret decreases TR80 significantly without a significant effect on developed tension (DT). Caldaret has minimal effects on SR Ca2+ uptake in normal rats, which is observed as increased SR Ca2+ uptake at uptake time of 20 and 30 s at the highest concentration of 10 μM. In diabetic rats, Caldaret increases SR Ca2+ uptake all over the range of uptake time. Both the initial rate of SR Ca2+ uptake and the amount of Ca2+ accumulated in the SR with longer uptake time are increased by Caldaret [2]. Caldaret limits the infarct size of the reperfused canine heart. The amelioration of intracellular Ca2+ handling dysfunction achieved by Caldaret leads to cardioprotective effects against reperfusion injury following prolonged ischemia [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Na+/Ca2+ exchanger | MCC135 | MCC 135 | Caldaret |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $195.00/1mg |
VIP6Y
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TargetMol Chemicals Inc.
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2025-11-02 | |
| $521.00/5mg |
VIP2Y
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TargetMol Chemicals Inc.
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2025-10-27 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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