Product Details
| Product Name:
CC0651 |
CAS No.:
1319207-44-7 |
| Supply Ability:
10g |
Release date:
2025/10/31 |
Product Introduction
Bioactivity
| Name | CC0651 |
| Description | CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme that potently inhibits the ubiquitination of p27Kip1 (IC50: 1.72 μM). |
| In vitro | CC0651 functions by stabilizing a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site. It completely inhibits polyubiquitin chain assembly, reduces the formation of free triubiquitin, and minimally affects hCdc34 monoubiquitin production, with no impact on diubiquitin production [1]. CC0651 significantly impairs the initiation rate of ubiquitin chains on substrates by SCFCdc4, as indicated by the monoubiquitination of Sic1 by K0 ubiquitin. Interestingly, CC0651 enhances the formation of ubiquitin dimers and monoubiquitinated hCdc34, consistent with the accumulation of the hCdc34 conjugate in cells treated with its ester derivative. A quantitative SCF ubiquitination assay using a β-Catenin substrate peptide determined an IC50 value of 18±1 μM for CC0651 inhibition, aligning with concentrations effective in NMR and TR-FRET assays [2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 56 mg/mL (126.61 mM), Sonication is recommended.
|
| Keywords | p27Kip1 ubiquitination | CC-0651 | CC0651 | CC 0651 |
| Inhibitors Related | NSC697923 | Alrizomadlin | T521 | PYZD-4409 | NAcM-OPT | Nutlin-3 | PYR-41 | NSC232003 | NAE-IN-M22 | Indole-3-carbinol | Idasanutlin | SPOP-IN-6lc |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$3100.00/100mg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-07-16 |
United States