E 0747 NEW
| Price | $293 | $436 | $722 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-02 |
Product Details
| Product Name: E 0747 | CAS No.: 99599-78-7 |
| Purity: 95.17% | Supply Ability: 10g |
| Release date: 2025/11/02 |
Product Introduction
Bioactivity
| Name | E 0747 |
| Description | E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels in cardiac cells. |
| In vivo | Intravenous injection of 3 mg/kg of E-0747 through a femoral vein cannula over a period of seconds using four canine models of ventricular arrhythmia: digitalis, sedation, arrhythmia, and heart failure concluded that E-0747 inhibits arrhythmia by inhibiting Na channels in cardiomyocytes[1];At a frequency of 1 Hz and a concentration higher than 3 X 10(-7) M, E-0747 decreased the maximum rate of rise (Vmax) of the action potential of Purkinje fibers in porcine heart, whereas the resting membrane potential was unchanged, and E-0747 inhibited Vmax in a rate-dependent manner.The inhibition was about 50% at a concentration of 3 X 10(-6) M with a stimulus of 3.3 Hz.[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SodiumChannel | Sodium Channel | E 0747 |
| Inhibitors Related | Phenytoin sodium | Procaine | Lidocaine Hydrochloride hydrate | Lidocaine | Safinamide | Valproic Acid | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Amitriptyline hydrochloride | Riluzole | Benzocaine |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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