Ethopropazine Hydrochloride NEW
| Price | Get Latest Price |
| Package | 1removed |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: Ethopropazine Hydrochloride | CAS No.: 1094-08-2 |
| Supply Ability: 10g | Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | Ethopropazine Hydrochloride |
| Description | Ethopropazine Hydrochloride is the salt form of Ethopropazine (Profenamine), a phenothiazine derivative with anticholinergic, antihistamine, and anti-adrenergic effects used in the treatment of Parkinson's disease, and acts as an AChE inhibitor by affecting the PAS active site. |
| In vitro | Ellman’s method was used to assess the inhibitory activity of Ethopropazine Hydrochloride on cholinesterases, with human recombinant acetylcholinesterase (hAChE) and human plasma butyrylcholinesterase (hBChE) as target enzymes, and acetylthiocholine chloride (ATChCl) as the substrate. In a 96-well plate, enzyme solution, the chromogenic reagent DTNB, and different concentrations of Ethopropazine Hydrochloride (10 mM to 1 nM) were added sequentially. The reaction was initiated by adding 1 mM ATChCl, followed by incubation at 37°C for 5 minutes. Absorbance changes were measured at 412 nm. The Results showed that Ethopropazine Hydrochloride strongly inhibited hBChE (IC₅₀ = 1.6 μM), while its inhibitory effect on hAChE was weaker (IC₅₀ = 1020 μM), making it a highly efficient and selective BChE inhibitor [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble), Sonication is recommended. DMSO : 20 mg/mL (57.32 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.73 mM), Sonication is recommended. |
| Keywords | Parphezein | Parfezin | Pardisol | Lysivane | Ethopropazine Hydrochloride | Dibutil |
| Inhibitors Related | 1-Naphthyl acetate | DL-Menthol | Ethyl (triphenylphosphoranylidene) acetate | 4-Methylbenzylidene camphor | Isoeugenol acetate | Diethyltoluamide | sn-Glycero-3-phosphocholine | Nizatidine | Coumaran | Methyl tridecanoate | Trimethylammonium chloride | Trimyristin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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