halazone NEW

halazone

Modify Date: 2024-01-02 12:05:36

halazone structure	Common Name	halazone
	CAS Number	80-13-7	Molecular Weight	270.09000
	Density	1.717 g/cm3	Boiling Point	437ºC at 760 mmHg
	Molecular Formula	C7H5Cl2NO4S	Melting Point	213ºC
	MSDS	N/A	Flash Point	218.1ºC

Purity		Quantity		Budget		Inquiry

Use of halazone Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water[1][2].

• Properties

• Spectrum

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 Names

Name	Halazone
Synonym	More Synonyms

 halazone Biological Activity

Description	Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Halazone is chemically closely related to Chloramine-T, the nitrogen atom is linked with two instead of one chlorine atom and, certainly more important here, a methyl group is replaced by a carboxyl group. The effect of Halazone on the sodium current is studied in voltage-clamped single nerve fibers of the frog. The oxidant Halazone drastically inhibits inactivation[1].
References	[1]. M Rack, et al. Effects of Some Chemical Reagents on Sodium Current Inactivation in Myelinated Nerve Fibers of the Frog. Biophys J. 1986 Oct;50(4):557-64. [2]. Rema Iyer, et al. Inhibition Profiling of Human Carbonic Anhydrase II by High-Throughput Screening of Structurally Diverse, Biologically Active Compounds. J Biomol Screen. 2006 Oct;11(7):782-91.

 Chemical & Physical Properties

Density	1.717 g/cm3
Boiling Point	437ºC at 760 mmHg
Melting Point	213ºC
Molecular Formula	C7H5Cl2NO4S
Molecular Weight	270.09000
Flash Point	218.1ºC
Exact Mass	268.93200
PSA	83.06000
LogP	2.76390
Stability	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

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