INF 195 NEW
| Price | $33 | $68 | $107 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: INF 195 | CAS No.: 1211379-56-4 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | INF 195 |
| Description | INF 195 is an inflammasome NLRP3 inhibitor that inhibits NLRP3-driven macrophage pyroptosis and IL-1β release. INF 195 reduces isoproterenol-induced hypertrophy in H9c2 rat myoblasts and can be used to study myocardial ischemia and myocardial infarction. |
| In vitro | INF 195 (0.1-100 μM, 72 hours) was able to inhibit macrophage pyroptosis and IL-1β release driven by NLRP3. At lower doses (5-10 μM, 10 min), INF 195 was able to reduce the infarct zone in isolated mouse hearts and effectively prevented myocardial ischemia/reperfusion injury.INF 195 (10 μM), as an ethyl ester precursor of the active metabolite 3-(3-(2-chlorophenyl)propanoyl)piperidine-1-carboxylic acid, was able to penetrate into H9c2 cardiomyoblasts, and hydrolyzed intracellularly to this active form. [1] |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (463.23 mM), Sonication is recommended. |
| Keywords | NLRP3 |
| Inhibitors Related | Stavudine | Disulfiram | Sodium Thiocyanate | 10-Hydroxydecanoic Acid | Inosine pranobex | Ethyl palmitate | Theophylline monohydrate | Balsalazide disodium dihydrate | 1,8-Cineole | NLRP3-IN-2 | Prednisone acetate | Lornoxicam |
| Related Compound Libraries | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Ovarian Cancer Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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