JNJ-26489112 NEW
| Price | $1080 | $1490 | $1970 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-10 |
Product Details
| Product Name: JNJ-26489112 | CAS No.: 871824-55-4 |
| Purity: 99.31% | Supply Ability: 10g |
| Release date: 2025/11/10 |
Product Introduction
Bioactivity
| Name | JNJ-26489112 |
| Description | JNJ-26489112 is a CNS-active agent and inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels with broad-spectrum anticonvulsant activity in rodents and can be used to study neurological disorders. |
| In vitro | JNJ-26489112 inhibited calcium inward flow under depolarizing conditions (fluorescence assay) with an IC50 value of 34 μM. When N-type channel activity was measured directly by whole-cell patch-clamp assay with low-frequency stimulation (0.07 Hz), JNJ-26489112 enhanced its inhibitory effect in a concentration-dependent manner with an IC50 of 70 μM. This compound is an activator of KCNQ2 channels, especially at -50 mV. [1] |
| In vivo | Intraperitoneal injection of JNJ-26489112 effectively prevented forelimb clonic seizures induced by bisuccinic acid (Bic), picric acid (Pic), or pentylenetetrazole (PTZ) in male CF-1 mice, with 1-hour ED50s of 197, 189, and 109 mg/kg.[1] In a pharmacokinetic study, after oral administration of 10 mg/kg JNJ-26489112 to adult male rats, plasma Cmax was 9090 ng/mL (33 μM), tmax was 53 minutes, bioavailability (F) was 95%, t1/2 was 8.2 hours, and the AUC (total exposure) was 53,200 ng-h/mL. At doses of 10, 30, and 300 mg/kg, a linear relationship between exposure and dose was observed. The volume of distribution (Vdss) was 390 mL/kg and clearance (CL) was 96 mL/h/kg after intravenous injection of 2 mg/kg. In female beagles, after oral administration of 10 mg/kg JNJ-26489112, Cmax reached 11,500 ng/mL (41 μM), tmax was 55 minutes, F was 83%, t1/2 was 20 hours, and the AUC was 212,000 ng-h/mL. after intravenous administration of 2 mg/kg, Vdss and CL were 630 mL/kg and 30 mL/h/kg, respectively.[1] |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | JNJ-26489112 |
| Inhibitors Related | Minoxidil sulfate | Phenytoin sodium | Procaine | Tannic acid | L-Ascorbic acid | Valproic Acid | Lidocaine hydrochloride | L-Aspartic aicd sodium | Ethyl cinnamate | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Indapamide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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