Lobeline Impurity 13 NEW

Product Information

Product Number: L045013

English Name: Lobeline Impurity 13

English Alias: (1S,1'S)-2,2'-((2S,6R)-1-methylpiperidine-2,6-diyl)bis(1-phenylethanol)

CAS Number: 1125824-42-1

Molecular Formula: C₂₂H₂₉NO₂

Molecular Weight: 339.47

Advantages

Analyzing the by-product formation mechanism of piperidine ring construction or chiral center formation during lobeline synthesis to optimize processes for controlling stereoisomer impurity generation;

Serving as a chiral reference standard containing bis(phenylethanol) structures to provide a standard substance for detecting chiral impurities in drugs, improving the accuracy of enantiomer separation and detection;

Helping study the impact of piperidine ring and phenylethanol structures on drug activity and metabolism to provide a scientific basis for impurity control strategies.

Applications

Drug Development: Used as a chiral impurity reference standard to identify and quantify Impurity 13 in lobeline preparations, evaluating the stereochemical purity of APIs and formulations;

Quality Control: Acting as a standard substance to validate the sensitivity of chiral HPLC or supercritical fluid chromatography (SFC) and other detection methods, ensuring chiral impurity content meets pharmacopoeia requirements during production;

Toxicological Research: Evaluating the potential impact of this chiral impurity on lobeline safety by comparing the biological effects of different configurations.

Background Description

Research Status

Chiral Synthesis Processes: Developing highly stereoselective impurity synthesis methods to obtain single-configuration reference standards through chiral catalysts or resolution techniques;

Chiral Detection Technologies: Establishing high-resolution enantiomer separation and detection methods using chiral stationary phase HPLC or LC-MS combined techniques;

Stereoisomeric Effects: Investigating the impact of this impurity on lobeline receptor binding ability and pharmacokinetics through in vitro activity experiments and animal models;

Process Control Strategies: Analyzing the influence of parameters such as reaction temperature and solvent polarity during piperidine ring formation on stereoselectivity to optimize conditions for reducing chiral impurity generation.