MPTP hydrochloride NEW
| Price | $30 | $46 | $85 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-05 |
Product Details
| Product Name: MPTP hydrochloride | CAS No.: 23007-85-4 |
| Purity: 99.65% | Supply Ability: 10g |
| Release date: 2025/11/05 |
Product Introduction
Bioactivity
| Name | MPTP hydrochloride |
| Description | MPTP hydrochloride is a dopamine neurotoxin and the precursor of MPP⁺. It can induce apoptosis and has the ability to cross the blood-brain barrier. MPTP hydrochloride is toxic to dopaminergic neurons and is commonly used for the construction of Parkinson's disease animal models. |
| In vitro | METHODS: Human neuroblastoma cells M17 were treated with MPTP hydrochloride (1-50 μM) for 48 h. The expression levels of target proteins were detected by Western Blot. RESULTS: MPTP hydrochloride promoted Tau protein phosphorylation in M17 cells. [1] METHODS: Neuroblastoma cell N2AB-1 and glioma cell C6 were treated with MPTP hydrochloride (0.33-33.7 μM) for 24 h, and the growth curves were examined. RESULTS: MPTP hydrochloride did not affect the cell number of actively growing N2AB-1 or C6 cells. [2] |
| In vivo | METHODS: To construct a subacute Parkinson's model, MPTP hydrochloride (30 mg/kg in 0.9% saline) was administered intraperitoneally to C57BL/6 mice once daily for five days. RESULTS: Subacute MPTP hydrochloride treatment did not cause significant motor deficits, although the dopaminergic system was severely impaired. mPTP hydrochloride significantly increased the level of α-synuclein and the number of astrocytes in the striatum and disrupted the blood-brain barrier in the substantia nigra pars compacta. [3] METHODS: To study the effects of different models on the behavior and pathology of a mouse model of Parkinson's disease, MPTP hydrochloride was used intraperitoneally to construct a subacute model group and a chronic model group. In the subacute model group, MPTP hydrochloride (30 mg/kg) was administered once daily for ten days. In the chronic model group, MPTP hydrochloride (30 mg/kg) was injected once every 3.5 days for five weeks for ten times. RESULTS: In the MPTP hydrochloride-induced subacute Parkinson's disease mouse model, there was a small loss of dopaminergic neurons in the midbrain, but there was no effect on the behavior.The MPTP hydrochloride-induced chronic Parkinson's disease mouse model lost a large number of dopaminergic neurons, which was accompanied by anxiety-like behaviors in addition to motor dysfunction. [4] |
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 10 mg/mL (47.68 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (4.77 mM), Sonication is recommended. DMSO : 23.86 mg/mL (113.77 mM), Sonication is recommended. |
| Keywords | penetrant | Parkinson's | neurotoxin | MPTP Hydrochloride | MPTP hydrochloride | MPTP | Inhibitor | inhibit | DopamineReceptor | Dopamine Receptor | Dopamine | Disease | brain | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | L-Glutamic acid monosodium salt monohydrate | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Ferroptosis Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Endocrinology-Hormone Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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