PI-103 Hydrochloride NEW
| Price | $34 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: PI-103 Hydrochloride | CAS No.: 371935-79-4 |
| Supply Ability: 10g | Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | PI-103 Hydrochloride |
| Description | PI-103 Hydrochloride is a potent dual inhibitor of PI3K and mTOR, demonstrating inhibitory IC50 values of 8 nM for p110α, 88 nM for p110β, 48 nM for p110δ, 150 nM for p110γ, 20 nM for mTORC1, and 83 nM for mTORC2, respectively. Additionally, it inhibits DNA-PK with an IC50 of 2 nM and induces autophagy [1] [2] [3] [4]. |
| In vitro | PI-103 is demonstrated to possess antiproliferative effects across various human cancer cell lines, acting essentially as a cytostatic agent by inducing cell cycle arrest in the G1 phase [1]. Additionally, it significantly inhibits leukemic proliferation, reduces the clonogenic potential of leukemic progenitors, and triggers mitochondrial apoptosis, particularly targeting the leukemic stem cell compartment [2]. It effectively targets both rapamycin-sensitive (mTORC1, IC 50=20 nM) and rapamycin-insensitive (mTORC2, IC 50=83 nM) complexes of the mTOR protein kinase, showcasing its potent inhibitory action [4]. |
| In vivo | PI-103 demonstrates therapeutic efficacy against various human tumor xenografts, displaying notable inhibition of angiogenesis, invasion, metastasis, along with direct antiproliferative effects [1]. Furthermore, it induces immunosuppression which facilitates in vivo tumor growth while inhibiting apoptosis. Moreover, tumors in mice treated with PI-103 exhibit elevated levels of cyclin D1 and an increased number of proliferating cells [3]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PI103 Hydrochloride | PI 103 Hydrochloride | PI-103 Hydrochloride |
| Inhibitors Related | Stavudine | Aceglutamide | Cysteamine hydrochloride | Hydroxychloroquine | Metronidazole | Guanidine hydrochloride | Citric Acid Triammonium | Tributyrin | Paeonol | Naringin | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $52.00/5mg |
VIP6Y
|
TargetMol Chemicals Inc.
|
2025-11-10 | |
| $97.00/2mg |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-07-16 | |
| $0.00/1kg |
VIP1Y
|
Hefei Lbao Physical & Chemical Science Co.,Ltd
|
2025-11-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY