PI3K/mTOR Inhibitor-1 NEW
| Price | $2120 | $2780 | $3700 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2026-01-05 |
Product Details
| Product Name: PI3K/mTOR Inhibitor-1 | CAS No.: 1949802-49-6 |
| Supply Ability: 10g | Release date: 2026/01/05 |
Product Introduction
Bioactivity
| Name | PI3K/mTOR Inhibitor-1 |
| Description | PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM). |
| In vitro | PI3K/mTOR Inhibitor-1 (Compound 26) is a potent dual PI3K/mTOR inhibitor, demonstrating high inhibitory activity against PI3Kα/β/γ/δ (IC50 = 20/376/204/46 nM) and mTOR (IC50 = 189 nM), potent suppression of AKT phosphorylation (IC50 = 196 nM), and excellent antiproliferative effects on cancer cells. Enzymic data and modeling simulations indicate that a cyclopropyl ring on the C4 sulfone chain and a fluorine on the C6 aminopyridyl moiety are responsible for its maintained PI3K activity and enhanced mTOR potency, respectively. |
| In vivo | PI3K/mTOR Inhibitor-1 (Compound 26) demonstrated superior antiproliferative effects in the HT-29 colorectal carcinoma xenograft model at daily doses of 3.75 and 7.5 mg/kg compared to BKM120 at doses of 15 and 30 mg/kg. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PI3Kδ | PI3Kγ | PI3Kβ | PI3Kα | PI3K/mTOR Inhibitor-1 | PI-3K/mTOR Inhibitor-1 | PI3K/mTOR Inhibitor1 | PI3K/mTOR Inhibitor 1 | mTOR |
| Inhibitors Related | Musk ketone | Stearamide | Myricetin | Creatine monohydrate | Hyaluronic acid | 4-Methylbenzylidene camphor | N-Hydroxyphthalimide | L-Proline | Isoprenaline hydrochloride | Methyl eugenol | Metformin hydrochloride | Dihydromyricetin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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