Sildenafil EP Impurity C NEW

Sildenafil EP Impurity C

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E-mail: anna@molcoo.com

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• English Version

• Product Information:
  Product Code: S005012
  English Name: Sildenafil EP Impurity C
  English Alias: 5-(2-hydroxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
  CAS No.: 139755-91-2
  Molecular Formula: C20H26N6O4S
  Molecular Weight: 446.52
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• Product Advantages:
  This product has high purity, which can accurately meet the strict requirements for impurity reference substances in sildenafil drug quality control and related research, especially complying with the standards of the European Pharmacopoeia (EP). It has good chemical stability and can maintain stable physical and chemical properties for a long time under standardized storage conditions, providing a strong guarantee for the repeatability and accuracy of experiments. Strict quality control is implemented during the production process, with small differences between batches, which can effectively reduce experimental errors and provide a reliable material basis for scientific research and production work.
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• Product Applications:
  It is mainly used in the quality control field of sildenafil, serving as Impurity C reference substance specified in the European Pharmacopoeia (EP) to detect the content of this impurity in sildenafil raw materials and various preparations, ensuring that the drug quality meets relevant standards. Moreover, in the research and development process of sildenafil, it can be used to explore the formation mechanism of this impurity and its impact on drug efficacy and safety, providing important data references for optimizing production processes and improving drug quality.
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• Background Description:
  Sildenafil is a selective phosphodiesterase type 5 (PDE5) inhibitor, mainly used in the treatment of male erectile dysfunction and pulmonary arterial hypertension. It works by inhibiting the PDE5 enzyme to increase the level of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis or pulmonary vascular smooth muscle. During its synthesis, storage and preparation processes, various impurities may be generated due to factors such as incomplete reactions, raw material impurities or degradation, and Sildenafil EP Impurity C is one of them (Impurity C specified in the European Pharmacopoeia). If the content of these impurities exceeds the standard, it may affect the efficacy and stability of the drug, and even bring potential safety risks. Therefore, accurate detection and strict control of them are of great significance.
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• Research Status:
  At present, research on Sildenafil EP Impurity C mainly focuses on the development and optimization of detection methods, such as high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS), to improve the sensitivity and accuracy of detection, meeting the requirements of standards such as the European Pharmacopoeia. At the same time, studies on the source, stability of this impurity and its interaction with the main component of sildenafil are also gradually deepening, providing a scientific basis for improving the quality standards and safety evaluation system of sildenafil.

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com