SK1-IN-1 NEW
| Price | $199 |
| Package | 1mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: SK1-IN-1 | CAS No.: 1218816-71-7 |
| Purity: 98.72% | Supply Ability: 10g |
| Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | SK1-IN-1 |
| Description | SK1-IN-1 is an orally available and potent sphingosine kinase 1 (SPHK1) inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases. |
| In vitro | SK1-IN-1 can inhibit sphingosine kinase 1 (SPHK1) with an IC50 value of 58 nM. |
| In vivo | b>METHODS: SK1-IN-1 (1 mg/kg, intravenous injection; 3 mg/kg, oral administration) was studied for its pharmacokinetic properties in rats. RESULTS: SK1-IN-1 showed moderate oral bioavailability and acceptable blood circulation half-life. The bioavailability of SK1-IN-1 in rats after oral administration was 17.6%, and the half-lives in rat blood circulation after intravenous injection and oral administration were 4.30 hours and 7.5 hours, respectively. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (8.28 mM), Sonication is recommended. DMSO : 80 mg/mL (200.75 mM), Sonication is recommended. |
| Keywords | SPHK1 | SK1-IN-1 | SK-1-IN-1 | SK1IN1 | SK1 IN 1 | S1PReceptor | S1P Receptor |
| Inhibitors Related | Fingolimod hydrochloride | SLP9101555 | BMS-960 | LX-2931 | CYM50374 | ASP-4058 | Ceranib-2 | Siponimod | Fingolimod | MP-A08 | Ozanimod | W140 HBr |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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