Product Details
| Product Name:
SQ28603 |
CAS No.:
100845-83-8 |
| Supply Ability:
10g |
Release date:
2025/08/22 |
Product Introduction
Bioactivity
| Name | SQ28603 |
| Description | SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP). |
| In vivo | In conscious DOCA/salt hypertensive rats, intravenous administration of 300 μmol/kg SQ28603 significantly reduces mean arterial pressure (MAP) from 177±12 to 154±8 mm Hg and increases urinary cyclic guanosine monophosphate (GMP) excretion from 204±70 to 1,068±326 pmol/kg/min within 2 hours. SQ28603 also reduces the NEP activity in the kidney by 95% (1.28±0.08 vs. 18.35±0.61 μmol/min for SQ28603 and vehicle, respectively) and in the lungs by 77% (0.29±0.03 vs. 0.92±0.14 μmol/kg for SQ28603 and vehicle, respectively). Consequently, inhibition of NEP activity by SQ28603 significantly decreases MAP, increases plasma ANP concentrations, and enhances urinary excretion of cyclic GMP in conscious DOCA/salt hypertensive rats[1]. Additionally, in conscious female cynomolgus monkeys, SQ28603 (300 μmol/kg, approximately 80 mg/kg, i.v.) significantly increases sodium excretion from 4.9±2.3 to 14.3±2.1 μequiv./min and cyclic 3',5'-guanosine monophosphate excretion from 118±13 to 179±18 pmol/min[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SQ-28603 | SQ28603 | SQ 28603 | NEP |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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$1980.00/50mg |
VIP4Y
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TargetMol Chemicals Inc.
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2025-08-21 |
United States