英文名称：
Mitomycin C
CAS号：
50-07-7
分子式：
C15H18N4O5
分子量：
334.33
EINECS号：
200-008-6
熔点
360 °C
沸点
471.14°C (rough estimate)
密度
1.2238 (rough estimate)
折射率
1.6800 (estimate)
储存条件
2-8°C
溶解度
H2O: 4 mL/vial Stock solutions should be filter sterilized and stored at 2-8 °C in the dark., clear to slightly hazy, blue to purple
酸度系数(pKa)
pKa 2.8(H2O,t =25,I=0.1) (Uncertain)
形态
powder
颜色
blue-gray
PH值
pH (0.5 g/l, 25℃ : )5.0～7.0
水溶解性
soluble
Merck
14,6215
BRN
7231816
稳定性
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent making it useful as an antibiotic antitumor product. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.
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