Name: RQ-00311651
CAS#: 1257116-00-9
Chemical Formula: C19H18F3N5O2
Exact Mass: 405.1413
Molecular Weight: 405.3812
Elemental Analysis: C, 56.29; H, 4.48; F, 14.06; N, 17.28; O, 7.89
Description: RQ-00311651 is a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. RQ-00311651 strongly suppressed T currents when tested at holding potentials of -65 ∼ -60 mV, but not -80 mV, in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also inhibited high K-induced Ca signaling in those cells.
IUPAC/Chemical Name: (1S,2S)-2-(1H-benzo[d]imidazol-2-yl)-N-((R)-1-(5-(2,2,2-trifluoroethoxy)pyrazin-2-yl)ethyl)cyclopropane-1-carboxamide
InChi Key: KXMXGSQKPDZCEW-WOPDTQHZSA-N
InChi Code: InChI=1S/C19H18F3N5O2/c1-10(15-7-24-16(8-23-15)29-9-19(20,21)22)25-18(28)12-6-11(12)17-26-13-4-2-3-5-14(13)27-17/h2-5,7-8,10-12H,6,9H2,1H3,(H,25,28)(H,26,27)/t10-,11+,12+/m1/s1
SMILES Code: O=C([C@@H]1[C@@H](C2=NC3=CC=CC=C3N2)C1)N[C@@H](C4=NC=C(OCC(F)(F)F)N=C4)C
Appearance: Solid powder
关键字： 1257116-00-9;
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