Description: AM 114 is a proteasome inhibitor. It is an inhibitor of chymotrypsin-like activity of the 20S proteasome. Also, AM-114 displays anticancer activity, inhibits cell growth in human colon cancer HCT116 p53+/+ cells.
Name: AM-114
CAS#: 856849-35-9
Chemical Formula: C20H21B2NO5
Exact Mass: 377.16058
Molecular Weight: 377.01
Elemental Analysis: C, 63.72; H, 5.61; B, 5.74; N, 3.72; O, 21.22
Synonym: AM-114; AM 114; AM114; Proteasome Inhibitor IX;
IUPAC/Chemical Name: ((1Z,1'Z)-(1-methyl-4-oxopiperidine-3,5-diylidene)bis(methanylylidene))bis(4,1-phenylene))diboronic acid
InChi Key: SRPIKXGUPAKTIZ-APGQMXJTSA-N
InChi Code: InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3/b16-10-,17-11-
SMILES Code: B(O)(O)c1ccc(cc1)/C=C/2\C(=O)/C(=C\c3ccc(cc3)B(O)O)/CN(C2)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
关键字： 856849-35-9;AM-114;
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