Description: AMG 009 is an orally active, small molecule CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) and DP (D prostanoid) dual antagonist, which was in preclinical development in the US for the treatment of asthma and allergic rhinitis.
Name: AMG-009
CAS#: 1027847-67-1
Chemical Formula: C26H26Cl2N2O7S
Exact Mass: 580.08378
Molecular Weight: 581.46
Elemental Analysis: C, 53.71; H, 4.51; Cl, 12.19; N, 4.82; O, 19.26; S, 5.51
Synonym: AMG-009; AMG 009; AMG009.
IUPAC/Chemical Name: 2-(4-(4-(butylcarbamoyl)-2-((2,4-dichlorophenyl)sulfonamido)phenoxy)-3-methoxyphenyl)acetic acid
InChi Key: DKSKRBVXRDGYAS-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H26Cl2N2O7S/c1-3-4-11-29-26(33)17-6-9-21(37-22-8-5-16(13-25(31)32)12-23(22)36-2)20(14-17)30-38(34,35)24-10-7-18(27)15-19(24)28/h5-10,12,14-15,30H,3-4,11,13H2,1-2H3,(H,29,33)(H,31,32)
SMILES Code: CCCCNC(=O)c1ccc(c(c1)NS(=O)(=O)c2ccc(cc2Cl)Cl)Oc3ccc(cc3OC)CC(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
关键字： 1027847-67-1;AMG-009;
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