产品属性:
产品名称 | 规格 | CAS号 | 型号 |
6-Methylmercaptopurine | 50mg 100mg 250mg 1g | 50-66-8 | EY-Y0163662 |
Cas No.50-66-8
别名 N/A
化学名 N/A
分子式 C6H6N4S
分子量 166.2
溶解度 DMF: 15 mg/ml,DMSO: 30 m/gml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
6-Methylmercaptopurine (6-MMP) is a metabolite of the purine synthesis and interconversion inhibitor 6-mercaptopurine .1 It is formed from 6-MP via methylation by thiopurine S-methyltransferase. Levels of 6-MMP are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP.2
1.Rieder, M.J., and Carleton, B.Pharmacogenomics and adverse drug reactions in childrenFront. Genet.578(2014) 2.van Egmond, R., Chin, P., Zhang, M., et al.High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatmentAliment. Pharmacol. Ther.35(10)1181-1189(2012)
关键字: 50-66-8;C6H6N4S;6-Methylmercaptopuri;
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