产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Adapalene-d3 | 500μg 1mg | 1276433-89-6 | EY-Y0163742 |
Cas No.1276433-89-6
别名 N/A
化学名 N/A
分子式 C28H25D3O3
分子量 415.5
溶解度 DMF: 5 mg/ml,DMSO: 5 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Adapalene-d3 is intended for use as an internal standard for the quantification of adapalene by GC- or LC-MS. Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).1,2,3,4,5 It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).2 It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.3 It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.2 Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.5,4 Formulations containing adapalene have been used in the treatment of acne vulgaris.
1.Kim, M.J., Ciletti, N., Michel, S., et al.The role of specific retinoid receptors in sebocyte growth and differentiation in cultureJournal of Investigative Dermatology114349-353(2000) 2.Hensby, C., Cavey, D., Bouclier, M., et al.The in vivo and in vitro anti-inflammatory activity of CD271: A new retinoid-like modulator of cell differentiationAgents Actions29(1-2)56-58(1990) 3.Tenaud, I., Khammari, A., and Dreno, B.In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesionsExp. Dermatol.16(6)500-506(2007) 4.Ocker, M., Herold, C., Ganslmayer, M., et al.The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitroInt. J. Cancer107(3)453-459(2003) 5.Shi, X.-N., Li, H., Yao, H., et al.Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinomaMol. Med. Rep.12(5)6501-6508(2015)
关键字： 1276433-89-6;C28H25D3O3;Adapalene-d3;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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