产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Apoptosis Activator 2 | 50mg 10mg 100mg 25mg | 79183-19-0 | EY-Y0163840 |
Cas No.79183-19-0
别名
化学名 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
分子式 C15H9Cl2NO2
分子量 306.1
溶解度 DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS(pH 7.2) (1:4): 0.25 mg/ml,Ethanol: 1 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Apoptosis Activator 2 is a small molecule apoptosis activator with IC50 value of about 4μM [1].
Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20μM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15μM cytochrome c. It is found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation. Moreover, this induction of apoptosis only occurs in tumor cell lines (such as breast, lung, colon, and epidermal cancer cell lines). Normal cell lines are resistant to Apoptosis Activator 2 [1, 2].
关键字： 79183-19-0;C15H9Cl2NO2;Apoptosis Activator ;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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