产品属性:
产品名称 | 规格 | CAS号 | 型号 |
Lipoxin B4 | 25μg 50μg 100μg | 98049-69-5 | EY-Y0164307 |
Cas No.98049-69-5
别名 N/A
化学名 5S,14R,15S-trihydroxy-6E,8Z,10E,12E-eicosatetraenoic acid
分子式 C20H32O5
分子量 352.5
溶解度 DMF: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
References:
[1]. Serhan, C.N., Hamberg, M., Samuelsson, B., et al. On the stereochemistry and biosynthesis of lipoxin B Proc. Nat. Acad. Sci. USA 83(7), 1983-1987 (1986).
[2]. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984).
[3]. Papayianni, A., Serhan, C.N., and Brady, H.R. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells Journal of Immunology 156, 2264-2272 (1996).
关键字: 98049-69-5;C20H32O5;Lipoxin B4;
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