产品属性:
产品名称
规格
CAS号
型号
CAY10575
1mg 5mg 10mg 25mg
916985-21-2
EY-Y0165632
Cas No.916985-21-2
别名 N/A
化学名 N/A
分子式 C22H21N3O6S2
分子量 487.6
溶解度 DMF: 1mg/mL,DMSO: 10mg/mL,DMSO:PBS(7.2pH) 1:4: 0.2mg/mL
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells and is thought to play a role in the immune response. CAY10575 is a benzimidazole analog that inhibits IKK-ε with an IC50 value of ~15.8 μM.
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