Product Name：Gramicidin
CAS No.：1405-97-6
Synonyms：Gramicidin A；短杆菌肽A
Catalog No.：218P141
Brand：HongTide（上海鸿肽生物）
Description：短杆菌肽A是由短芽孢杆菌产生的一种抗生素，为线状十五肽，N端甲酰化封闭氨基，C端是醛基。短杆菌肽A能够杀死某些微生物．两个短杆菌肽A分子从膜两侧相对插入可形成穿膜通道，提高生物膜对某些一价阳离子的通透性，使这些物质顺浓度梯度通过细胞膜，不过短杆菌肽A并不显著提高运输速度。研究显示短杆菌肽A能抑制T7噬菌体DNA的转录，抑制膜结合的表皮腺苷酸三磷酸酶活性和体外阻抑人淋巴细胞转化。在大鼠动物模型中能延长心脏移植存活率。
Gramicidin A is an antibiotic produced by Bacillus subtilis, which is a linear pentapeptide with N-terminal formylation blocking amino group and C-terminal aldehyde group. Short peptide A can kill certain microorganisms. Two short peptide A molecules can be inserted relative to each other from both sides of the membrane to form transmembrane channels, improving the permeability of the biofilm to certain monovalent cations, allowing these substances to pass through the cell membrane in a concentration gradient. However, short peptide A does not significantly improve transportation speed. Studies have shown that short peptide A can inhibit the transcription of T7 bacteriophage DNA, inhibit membrane bound epidermal adenosine triphosphatase activity, and inhibit human lymphocyte transformation in vitro. It can prolong the survival rate of heart transplantation in rat animal models.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | For-VGA-d-LA-d-VVVWLW-d-LW-d-LWG-ol |
Sequence(3-letter code) | For-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-Gly-ol |
Peptide Structure | 
|
Molecular Formula | C99H140N20O17 |
Molecular Weight | 1882.3 |
订购联系方式：
上海鸿肽生物科技有限公司
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QQ: 3259098395
邮箱：sales1@hongtide.com
关键字： 1405-97-6;Gramicidin A;短杆菌肽A;Gramicidin;多肽;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。