Host:Rabbit
Target Protein:Klotho
IR:Immunogen Range:401-500/1012
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:9365
Swiss Prot:Q9UEF7
Source:KLH conjugated synthetic peptide derived from human Klotho:401-500/1012
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
.
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！
关键字： Klotho; 克老素;Klotho peptide;KL antibody KLOT_HUM;Klotho-peptide;
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