Wuhan hengheda Pharm offers high quality 4-O-Methylhonokiol, 4-O-Methylhonokiol is a naturally occurring lignan derived primarily from the bark and seeds of Magnolia officinalis and related species, which have been utilized in traditional medicine for centuries. Chemically, it is a methylated derivative of honokiol, characterized by the addition of a methoxy group (-OCH₃) at the 4-position of the biphenyl core structure. This modification enhances its lipophilic properties, potentially improving membrane permeability and bioavailability compared to its parent compound. With a molecular formula of C₂₁H₂₄O₂ and a molecular weight of 316.4 g/mol, 4-O-methylhonokiol exhibits structural similarities to other magnolia-derived bioactive compounds, such as honokiol and magnolol, yet demonstrates distinct pharmacological profiles due to its unique substitution pattern.
Extensive preclinical studies have highlighted 4-O-methylhonokiol’s multifaceted biological activities. It exhibits potent anti-inflammatory and antioxidant effects, primarily through the inhibition of NF-κB and MAPK signaling pathways, making it a candidate for treating chronic inflammatory conditions, including neurodegenerative diseases and metabolic disorders. Furthermore, its anxiolytic and neuroprotective properties—mediated via modulation of GABAergic systems and activation of Nrf2-mediated antioxidant responses—suggest therapeutic potential for anxiety, depression, and Alzheimer’s disease. Emerging evidence also points to anti-cancer activity, where it induces apoptosis and suppresses metastasis in various cancer cell lines by targeting PI3K/AKT and Wnt/β-catenin pathways. Additionally, its ability to improve insulin sensitivity and mitigate oxidative stress in metabolic models underscores its relevance in addressing obesity-linked complications. Despite promising preclinical data, further research is required to evaluate its pharmacokinetics, safety profile, and efficacy in clinical settings, paving the way for potential pharmaceutical or nutraceutical applications.
关键字： 厚朴;厚朴酚;和厚朴酚;
武汉恒和达生物医药有限公司成立于2013年，湖北省高新技术企业，主要从事原料药、高端医药中间体、分子砌块的研发与生产，恒和达生物经过多年拼搏，凭借产品的优良质量以及自身优异的合成和供应能力，获得业界广泛认可。