Trans-3-Hydroxy-L-proline is a hydroxylated derivative of the amino acid proline, specifically hydroxylated at the 3-position in the trans configuration. It is a non-proteinogenic amino acid that occurs naturally in certain biological systems, especially in collagen, where it plays a key role in stabilizing the triple-helical structure. Unlike the more common 4-hydroxyproline, which is abundant in animal collagen, trans-3-hydroxy-L-proline is found in specific collagen types and plant cell wall proteins such as extensins.
Structurally, it retains the pyrrolidine ring of proline but with an additional hydroxyl group at the third carbon. This modification impacts its conformational flexibility and hydrogen bonding capability, influencing protein folding and stability. Due to these characteristics, trans-3-hydroxy-L-proline is of interest in biomedical research, especially in the study of collagen-related diseases and in the design of collagen-mimetic peptides.
In synthetic chemistry and pharmaceutical development, this compound is also used as a chiral building block. Its stereochemistry and functional groups allow for selective derivatization, making it valuable in asymmetric synthesis and peptide engineering.
关键字： amino acid proline;pharmaceutical ;
武汉恒和达生物医药有限公司成立于2013年，湖北省高新技术企业，主要从事原料药、高端医药中间体、分子砌块的研发与生产，恒和达生物经过多年拼搏，凭借产品的优良质量以及自身优异的合成和供应能力，获得业界广泛认可。